P-660 No association between BMI, oocyte yield and maturation following different trigger strategies: a large observational study including 5000 cycles.

Abstract Study question Is patients’ BMI associated with oocyte yield and maturation following different trigger strategies r-hCG, GnRH agonist (GnRHa) or dual trigger? Summary answer Patients’ is not triggering rhCG, GnRHa trigger. What known already Triggering final a key step of ovarian stimulation for IVF/ICSI treatment. Although hCG has traditionally been the gold standard maturation, increasingly used as optimal in “freeze-all” era. Recent evidence demonstrated excellent results dual-trigger, combination GnRHa. Despite this swift clinical practice, early studies that plasma levels depend on dose BMI. Furthermore, although dose-finding equal efficacy triptorelin doses ranging from 0.1-0.4mg, these pertained only to low patients. design, size, duration This retrospective observational study including 5190 consecutive cycles (OS) performed between January 2019 -September 2022 tertiary Fertility Unit within University Affiliated Hospital. Overall were analyzed: 2691 triggered subcutaneous administration 0.2 mg (triptorelin), 1110 250 mcg r-hCG 1389 (combination both triptorelin+ r-hCG). Participants/materials, setting, methods Ovarian was recombinant FSH HMG at starting 150-300IU depending reserve Control LH surge accomplished by flexible antagonist PPOS protocol. The primary outcome measures rate (MII/oocytes) FOI (oocytes/AFC); secondary outcomes MII yield. Multivariable regression models evaluate interaction type relation study’s outcomes. Main role chance Overall, significantly types mainly due fact freeze-all cases, reserve. resulted higher number oocytes (15.95 ± 8.88) MIIs (12.31 7.27) compared rhCG (7.83 5.42 5.86 4.22 respectively) (8.51 5.70 6.44 4.54 utilized. Nonetheless, when comparable groups (% [95% CI]): 77.2 [76.6; 77.8] vs 74.9 [73.3; 76] 75.6 [74.5; 76.7]. analysis, adjusting confounding factors, (OR:1.00 CI: 0.99;1.01]) (Beta 0.52 -0.49;1.54]). Similarly 0.02 -0.08; 0.13]) 0.01 0.10]) retrieved. Interactions considered each model. All analyses conducted considering weight, but no association revealed. Limitations, reasons caution study, we cannot exclude presence residual bias despite large series, multiple indexes like adopted account factors. Wider implications findings previous small supported an levels, our analysis > 5000 clearly shows efficiency patient's significant differences found FOI. Trial registration Not applicable